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picture1_Protein Diet Pdf 140346 | Diet Supplements Duis 2020


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File: Protein Diet Pdf 140346 | Diet Supplements Duis 2020
july 29 2020 low glycemic index therapy ketogenic diet and supplements as treatments for angelman syndrome jessica duis md ms director angelman dup15q clinic jessica duis childrenscolorado org why consider ...

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        JULY 29, 2020
        Low glycemic index 
        therapy, ketogenic 
        diet, and 
        supplements as 
        treatments for 
        Angelman syndrome
        Jessica Duis, MD, MS
        Director, Angelman/Dup15q clinic
        Jessica.duis@childrenscolorado.org
                               Why consider diet?
                                                                     Before KD
                                                                2 years following KD initiation
                                                    Studies have shown that 30% to 60% of 
                                                   patients with DRE who use the KD have at 
                                                   least a 50% reduction in seizure frequency at 
                                                   6 months
                  Mechanism of action
                                          Seizure efficacy
                                     • During ketosis, there is more efficient 
                                       synaptic removal of glutamate, the brain's 
                                       major excitatory neurotransmitter. Its 
                                       conversion to gamma-aminobutyric acid, 
                                       a major inhibitory neurotransmitter, via 
                                       the glutamate/gamma-aminobutyric acid–
                                       glutamine cycle leads to neuronal 
                                       inhibition.
                                     • Acetoacetate and BHB inhibit glutamate 
                                       neurotransmission by inhibiting activation 
                                       of vesicular glutamate transporters.
                                     • KD also improves mitochondrial 
                                       dysfunction associated with 
                                       epileptogenesis.
                    Types of Diet
                                        Ketogenic Diet
                                         ● Fat to Carb + 
                                           Protein Ratio
                                        Low Glycemic Index 
       Regular Diet   KD
               LGIT
                                        Treatment
                                         ● 40-60g low 
                          Carbohydrates
                                           glycemic carbs per 
                          Protein
                                           day
                          Fat
                                        Modified Atkins
                                         ● 10-20g net carbs 
                                           per day
                                        *All diets are to be 
                                        medically followed by a 
                                        doctor and dietitian
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...July low glycemic index therapy ketogenic diet and supplements as treatments for angelman syndrome jessica duis md ms director dupq clinic childrenscolorado org why consider before kd years following initiation studies have shown that to of patients with dre who use the at least a reduction in seizure frequency months mechanism action efficacy during ketosis there is more efficient synaptic removal glutamate brain s major excitatory neurotransmitter its conversion gamma aminobutyric acid inhibitory via glutamine cycle leads neuronal inhibition acetoacetate bhb inhibit neurotransmission by inhibiting activation vesicular transporters also improves mitochondrial dysfunction associated epileptogenesis types fat carb protein ratio regular lgit treatment g carbohydrates carbs per day modified atkins net all diets are be medically followed doctor dietitian...

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